Recently I talked about a study on Good Morning America showing that although statins effectively reduce low-density lipoprotein (LDL) cholesterol, they also appear to reduce patients’ levels of energy and activity. I discussed 5 ways to deal with the problem of low energy or fatigue while on statins. The response was tremendous and I have learned what my own patients have been telling me for some time – not all people tolerate statins without side effects. Complaints of memory problems, fatigue, low energy, muscle weakness were fairly common although with over 13 million users it is hard to know how many people overall suffer.

Yet giving people the heads up that side effects can occur while on statins is important. I believe many patients are led to think they are crazy when their doctors tell them that the symptoms aren’t likely from statins or they wrongly attribute the symptoms to something else rather than try stopping the statins, lowering the dose, or switching to another brand.  So many doctors believe the statin drugs are so safe and effective that the “joke” or discussion in the medical community is that perhaps most healthy adults would benefit from a low dose of statins just to prevent heart disease. “Perhaps we should put statins in the drinking water”, a few will suggest.

Back to the reason for this piece!! In the segment, I included the suggestion to try juices high in antioxidants such as pomegranate juice, a recommendation learned from my patients over the years. However I also noted on the show that grapefruit juice should be avoided as it could interfere with metabolism of the statin medication and raise the drug level and potential side effects even more. An astute viewer contacted me and alerted me that there is a similar interaction of pomegranate juice with statins and that pomegranate juice should also be avoided. I did a little homework and found that a study performed on rats (which means we don’t know if the effect will be the same in humans) in Japan and published in 2005 did find that pomegranate juice, like grapefruit juice, could potentially interfere with the metabolism of certain medications.

Fruits and many pure unsweetened fruit juices are great sources of antioxidants, vitamins, potassium and fiber and are an essential part of a heart-healthy diet. Yet with so many people on statins to treat or prevent heart disease and stroke, it would seem that much more attention should be paid to the grapefruit and pomegranate fruit interaction with statins. Perhaps these juices should add this potential interaction on their label and include the information in their marketing campaigns. I know that I will do my part to spread the word to my patients and audiences that I speak to.

Many viewers asked about the origin of the study on statins and fatigue. The research was done by Dr. Beatrice Golomb and presented at the American Heart Association’s 49th Annual Conference on Cardiovascular Disease Epidemiology and Prevention, held Mar. 10 to 14 in Palm Harbor, Fla. According to Dr. Golomb, M.D. 1,016 adults who were free of diabetes or heart disease but had high LDL levels received either simvastatin, pravastatin or placebo for six months. The researchers found that although both statins effectively lowered LDL cholesterol, pravastatin was associated with a significantly higher proportion of patients who rated both their energy and activity levels as “much worse” and that simvastatin was associated with a significantly higher proportion of patients who rated their energy level as “much worse.

What has been your experience with statins? Do you routinely avoid grapefruit or pomegranate juice while on statins? Have you tried coenzyme Q-10? What were the results?

As always, I welcome your questions and comments.

Dr. Marie Savard
ABC News Medical Contributor

Dr. Savard is working on a new book, Ask Dr. Marie: Straight Talk and Reassuring Answers to Your Most Private Questions
Her health management system is available at her website,

Go to the Ask Dr. Marie Home Page | Dr. Marie's Home Page


  1. Jessie Says:

    free grapefruit diet

    I personally agree with your comments, but there will always be some people who may not feel the same.

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  13. curt Says:

    If Grapefruit juice increases the level of Statins in the bloodstream, would it not follow then, that a small dose of grapefruit juice may be beneficial in increasing the effectiveness? has this been studied? Should it be? Grapefruit and Statins- was this interaction found in a Rat study? Or humans?

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  17. Bill Says:

    After I started taking Lipitor (theh smallest dose, 15mg?), my calves got very sore so I stopped taking it. After a few weeks, my doctor suggested trying Lipitor again so I did. The second time around, I got no soreness and my LDLs went down to the mid 70s. Although I can’t remember what number was associated with my LDLs before that, I remember it varied from borderline elevated to elevated.

    When I first read about pomegranate juice unclogging arteries, I started drinking it. I haven’t noticed any adverse effects but I haven’t noticed any good ones either.

    I found 2 scientific papers that showed how great pomegranate juice. They were both from the same University, had at least 1 author in common, and followed very few patients. I wonder how valid these studies are.

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