For the first time ever, obstetricians and psychiatrists have issued joint guidelines for the treatment of women with depression who are pregnant and for those thinking about getting pregnant. I was stunned to learn that there were no specific guidelines to help women and their doctors before now.  

I talked about these guidelines on Good Morning America and commented on World News as well. To summarize the detailed and comprehensive report: Experts believe that the risk of untreated depression to the health of the mother and baby are considerable and should be balanced against the risk of treatment with medications. They recommend that women with mild or controlled depression should try to wean off their medications before becoming pregnant. Psychotherapy such as talk therapy should always be used for women with depression and that this therapy may be enough for many women.  

However they are recommending continuing or even beginning antidepressant medication in pregnant women with severe depression for which no other treatment has been effective. It is this information that gained the most media attention and has many women understandably worried. The report does emphasize that there needs to be a lot more research on the short term and long term risk of these medications. Both untreated depression and use of antidepressants have been linked to smaller birth weights and even premature births along with possible problems for the baby after birth. Antidepressants have been linked to a combination of symptoms in the baby in the immediate postpartum period such as rapid pulse and a drop in blood sugar. They attribute these symptoms either directly to the medication or to the withdrawal of the medication. So any baby born to a mother on these medications needs to be monitored closely for these symptoms at birth. Developmental problems in the baby have also been raised – however the report mentions that both untreated depression and medications may increase the risk. 

As an internist treating women since the 1970’s, I have always been cautious about recommending any medication, including the popular SSRI’s such as Prozac, during pregnancy. Before SSRI’s, women took older antidepressants such as amitriptyline
 that have more side effects but can be an important option for women. 

I believe that many women should wean off their medications before they get pregnant if they can. Psychotherapy, including couples counseling, are helpful treatments that I find are not used often enough. All too often it is easier for doctors to write a prescription rather than refer a patient for some form of talk or cognitive therapy. Then again, insurance has not been as quick to reimburse for this helpful treatment and doctors don’t always know who are the therapists who can best treat their patients. There are many different types of practitioners – from social workers to psychologists and psychiatrists. Only psychiatrists can prescribe medication – and some are more experienced at managing women in pregnancy than others. Cost and access to a good therapist then becomes another barrier to women getting the best care. I think the report should include a guide for doctors to help them refer the right patient to the right therapist. This is not something we are taught in medical school despite the fact that that this form of therapy can be so important and the range of therapy options are so considerable. 

I have treated many women who have decided to delay a pregnancy – or not get pregnant at all – because of their fear of their depression returning without medication. They knew all too well that the research studying these medications has been limited. It is always difficult to study a medication objectively when a randomized controlled trial cannot be reasonably done. So the information we have on antidepressants comes from women who have stayed on their medication for one reason or another and likely many of these women had more severe underlying depression that may have affected the health of their baby as well.  

I believe this report should give women with severe depression some assurance that they are not alone and that many other women in their circumstances are making the same difficult choice to continue medications. Women with severe depression and those who have been suicidal in the past have a much higher chance of relapsing if medications are stopped. Relapse can occur during the pregnancy affecting the health of the mother and the baby – and after the pregnancy during the post partum period. Taking medication for them may be their only choice - and it is always a difficult one. Medication sometimes can be the only treatment that works. 

To summarize, the purpose of this report was to share with doctors all the research on the risks of untreated and treated depression in pregnancy including the known risk to the mother and to the baby. Experts emphasized over and over that the risks of untreated depression are considerable to the baby as well as the mother and that treatment with drugs like SSRI’s need to be considered sometimes. Unfortunately there is very little research on the effects of these medications and I do share the concerns of the many women who wrote to me about this. There are some women with severe depression who make the decision with the advice of their doctors to take the medication during pregnancy as they see they have no other choice. It is hard to disagree with their very personal decision.  

The experts all agreed that much more research must be done. I know this is little help for women who need to make this difficult decision now.  

What has been your experience with medications during pregnancy? What are your thoughts about this report and the new guidelines? 

As always, I welcome your questions and concerns. 

Warm regards, 

Dr. Marie

Go to the Ask Dr. Marie Home Page | Dr. Marie's Home Page


  1. Ventego Says:

    Are you a professional journalist? You write very well.

  2. Shoshana Bennett Says:

    Whether or not a pregnant woman should begin or continue the use of an antidepressant needs to be decided by her and her physician. The prescribing doctor should understand this specialized area of medicine well. There are many risks to the pregnant mother and her developing baby if she does not receive proper treatment. Depression is potentially dangerous during pregnancy for a number of reasons. One, if the mother goes untreated, she is at greater risk of neglecting her prenatal care. She may not eat properly or attend prenatal visits regularly, and she may be tempted to self-treat with alcohol, smoking, or other harmful substances. Two, depression causes preterm labor, and research is also beginning to indicate that depression in the pregnant mother can negatively impact the baby’s development. In addition, the mom is at high risk for developing postpartum depression. Whether she takes an antidepressant, uses alternative and natural treatments, or a combination of both, she should work with a psychotherapist who specializes in the field of perinatal mood and anxiety disorders. One fact is clear – depression in pregnancy requires treatment or else she and her entire family can be negatively impacted – including those not yet born.

    Shoshana Bennett, Ph.D.
    Author, Postpartum Depression For Dummies and Pregnant on Prozac

  3. Miracle Doctor Says:

    As in any ailment, taking medicines for pregnant women should be prescribed by doctors. There are also home remedies available in treating depression. I also agree with you that counselling is one of the best treatment of depression especially for pregnant women.

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